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Article

Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos

4 Jan 2022

Abstract excerpt

Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of chromatin states in establishing developmental gene poising in preZGA zebrafish embryos. Poising is established at promoters and enhancers that initially contain...

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PMID: 34982026
DOI: 10.7554/elife.67738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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