Article

Fetal signatures in the 3D genome of iPSC-derived neurons and their implications for disease modeling

2025-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Induced pluripotent stem cells (iPSCs) have revolutionized neuroscience, providing an approach to generate patient-specific neurons for modeling of neurological diseases. However, it remains unclear how closely iPSC-derived neurons replicate the chromatin architecture of authentic brain neurons. Here, we uniformly process datasets for 228 human and 89 mouse Hi-C and Snm3C-seq samples of differen...

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Literature Corpus work: 6cb223d3-e07c-5727-8917-c18aee906437
DOI: 10.1101/2025.08.03.667702

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