Article

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs

2023-11-28

Abstract excerpt

Polycomb Repressive Complex 2 (PRC2)-mediated histone H3K27 tri-methylation (H3K27me3) recruits canonical PRC1 (cPRC1) to maintain heterochromatin. In early development, polycomb-regulated genes are connected through long-range 3D interactions which resolve upon differentiation. Here, we report that polycomb looping is controlled by H3K27me3 spreading and regulates target gene silencing and cell fate specification...

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Literature Corpus work: fc47df53-6056-5036-9c68-062a5ec245e6
DOI: 10.1101/2023.11.28.567931

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