Article

Network analysis of promoter interactions reveals the hierarchical differences in genome organisation between human pluripotent states

2019-12-13

Abstract excerpt

<h4> S UMMARY </h4> A complex and poorly understood interplay between 3D genome organisation, transcription factors and chromatin state underpins cell identity. To gain a systems-level understanding of this interplay, we generated a high-resolution atlas of annotated chromatin interactions in naïve and primed human pluripotent stem cells and developed a network-graph approach to examine the atlas at multiple sp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 858c7187-3449-5384-8344-4d8c85952cf5
DOI: 10.1101/2019.12.13.875286

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Network analysis of promoter interactions reveals the hierarchical differences in genome organisation between human pluripotent statesDOI 10.1101/2019.12.13.875286Read

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotencySemantic proximity Read

Analysis of regulatory network modules in hundreds of human stem cell lines reveals complex epigenetic and genetic factors contribute to pluripotency state differences between subpopulationsSemantic proximity Read

The regulatory architecture of the primed pluripotent cell stateSemantic proximity Read

Epigenomic and 3D genome architecture in naïve and primed human embryonic stem cell statesSemantic proximity Read

Integrating epigenomic features reveals principles of chromatin-state organizationSemantic proximity Read

Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogrammingSemantic proximity Read

Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cellsSemantic proximity Read

Minimum entropy framework identifies a novel class of genomic functional elements and reveals regulatory mechanisms at human disease lociSemantic proximity Read

A Perturbation Cell Atlas of Human Induced Pluripotent Stem CellsSemantic proximity Read

Specialised super-enhancer networks in stem cells and neuronsSemantic proximity Read

Discovery of Competent Chromatin Regions in Human Embryonic Stem CellsSemantic proximity Read

Decoding molecular markers and transcriptional circuitry of naive and primed states of human pluripotencySemantic proximity Read