Article

Single-cell epigenomic reconstruction of developmental trajectories in human neural organoid systems from pluripotency

2023-09-13

Abstract excerpt

Human cell type diversity emerges through a highly regulated series of fate restrictions from pluripotent progenitors. Fate restriction is orchestrated in part through epigenetic modifications at genes and regulatory elements, however it has been difficult to study these mechanisms in humans. Here, we use organoid models of the human central nervous system and establish single-cell profiling of histone modificatio...

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Literature Corpus work: 84280648-d647-5a1f-a5a7-b516616791f0
DOI: 10.1101/2023.09.12.557341

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