Article

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

2022-03-23

Abstract excerpt

Progressive fibrosis and maladaptive organ repair result in significant morbidity and millions of premature deaths annually. Senescent cells accumulate with ageing and after injury and are implicated in organ fibrosis, but the mechanisms by which senescence influences repair are poorly understood. Using two murine models of injury and repair we show that obstructive injury generates senescent epithelia which persi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 708fa2ca-8c4e-53ce-8655-360dc3e2e144
DOI: 10.1101/2022.03.21.485189

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosisDOI 10.1101/2022.03.21.485189Read

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic StrategiesSemantic proximity Read

Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future DirectionsSemantic proximity Read

Cellular senescence and the senescence-associated secretory phenotype: Potential therapeutic targets for renal fibrosis.Semantic proximity Read

Cellular Senescence in the KidneySemantic proximity Read

Multiomic analysis of human kidney disease identifies a tractable inflammatory, pro-fibrotic tubular cell phenotypeSemantic proximity Read

Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneysSemantic proximity Read

Aging and senescence-associated analysis of the aged kidney glomerulus highlights the role of mesangial cells in renal agingSemantic proximity Read

Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGFβ signalling pathway.Semantic proximity Read

Targeting cellular senescence in kidney diseases and aging: A focus on mesenchymal stem cells and their paracrine factorsSemantic proximity Read

Cellular senescence of renal tubular epithelial cells in acute kidney injurySemantic proximity Read

Senescence of alveolar stem cells drives progressive pulmonary fibrosisSemantic proximity Read

Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosisSemantic proximity Read