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Multiomic analysis of human kidney disease identifies a tractable inflammatory, pro-fibrotic tubular cell phenotype

2024-02-20

Abstract excerpt

<title>Abstract</title> <p>Maladaptive proximal tubular cells have been implicated in failure of repair following renal injury in rodent models, however whether this translates to human kidney disease is unknown. Hence, we integrated snRNA-ATAC-seq with single-cell molecular imaging to generate a multiomic atlas of human kidney disease. In injured kidneys, a subset of tubular epithelial cells acquired an inflamma...

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Literature Corpus work
1cc60871-9720-5a3b-a7bc-67405debba16
DOI
10.21203/rs.3.rs-3964901/v1
Open publication

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