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Cellular Senescence in the Kidney

18 Apr 2019

Abstract excerpt

Senescent cells have undergone permanent growth arrest, adopt an altered secretory phenotype, and accumulate in the kidney and other organs with ageing and injury. Senescence has diverse physiologic roles and experimental studies support its importance in nephrogenesis, successful tissue repair, and in opposing malignant transformation. However, recent murine studies have shown that depletion of chronically...

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PMID: 31000567
DOI: 10.1681/asn.2018121251

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