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Generation of a conditional cellular senescence model using proximal tubule cells and fibroblasts from human kidneys

14 Aug 2024

Abstract excerpt

Abstract Emerging evidence highlights cellular senescence’s pivotal role in chronic kidney disease (CKD). Proximal tubule epithelial cells (PTECs) and fibroblasts are major players in CKD and serve as cellular sources of senescence. The generation of a conditionally immortalized human kidney cell model would allow to better understand the specific mechanisms and factors associated with cellular senescence in a...

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PMID: 39143064
DOI: 10.1038/s41420-024-02131-y

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