Article

Senescence of alveolar stem cells drives progressive pulmonary fibrosis

2019-10-28

Abstract excerpt

Tissue fibrosis is a common pathological outcome of chronic disease that markedly impairs organ function leading to morbidity and mortality. In the lung, idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Here, we show that alveolar type 2 (AT2) stem cells isolated from IPF lung tissue exhibit characteristic transcriptomic features...

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Literature Corpus work: 4eda5738-0d4b-5a8a-9900-9be6a068c4b6
DOI: 10.1101/820175

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