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Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions

26 May 2020

Abstract excerpt

Cellular senescence refers to a cellular phenotype characterised by an altered transcriptome, pro-inflammatory secretome and generally irreversible growth arrest. Acutely senescent cells are widely recognised as performing key physiological functions in vivo promoting normal organogenesis, successful wound repair and cancer defence. In contrast, the accumulation of chronically senescent cells in response to...

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PMID: 32528288
DOI: 10.3389/fphar.2020.00755

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