Article

Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosis

2019-11-25

Abstract excerpt

Stem cell senescence is often seen as an age associated pathological state in which cells acquire an abnormal and irreversible state. Here, we show that alveolar stem cell differentiation during lung regeneration involves a unique previously uncharacterized transitional state that exhibits cardinal features normally associated with cell senescence. Specifically, using organoid cultures, multiple in vivo injury mo...

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Literature Corpus work: 81528a8b-8908-5b9c-ae4a-c3aa0f23c96f
DOI: 10.1101/855155

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