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Cellular senescence and the senescence-associated secretory phenotype: Potential therapeutic targets for renal fibrosis.

Experimental gerontology - 1 Aug 2021

Wang Wen-Juan, Chen Xiang-Mei, Cai Guang-Yan

Abstract excerpt

Renal fibrosis plays a crucial role in the progression of chronic kidney disease and end-stage renal disease. However, because the aetiology of this pathological process is complex and remains unclear, there is still no effective treatment. Cellular senescence and the senescence-associated secretory phenotype (SASP) have been reported to lead to renal fibrosis. This review first discusses the relationships among...

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PMID: 33984448
DOI: 10.1016/j.exger.2021.111403

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