Article
Inter-organ transmission of hepatocellular senescence induces multi-organ dysfunction through the TGFβ signalling pathway.
2021-12-14
Abstract excerpt
<title>Abstract</title> <p>Cellular senescence is associated with aging but also impacts various physiological and pathological processes such as embryonic development and wound healing. Factors secreted by senescent cells can affect their microenvironment, including local spreading of senescence. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure....
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Identifiers and source
- Literature Corpus work
- 2146f94c-84d3-5f00-b6a7-985b2e03ea68
- DOI
- 10.21203/rs.3.rs-1133747/v1