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Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

11 Dec 2020

Abstract excerpt

Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a state of accelerated and premature aging. Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and...

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PMID: 33362554
DOI: 10.3389/fphar.2020.601325

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