Article

Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases

2026-05-07

Abstract excerpt

CRISPR-associated transposons (CASTs) are Tn7-like elements that have co-opted RNA-guided CRISPR effectors for targeted DNA insertion. CASTs have been adapted as genome editing tools for programmable, site-specific integration. Among them, the type I-F system from Ps e udoalteromonas ( Pse CAST) shows uniquely robust activity in human cells, yet its mechanistic basis remains poorly understood. Here, we present...

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Literature Corpus work: 6e001336-bd2e-56de-835c-f8f8bdbd03af
DOI: 10.64898/2026.05.05.722991

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