Article

Structure-based recasting of a mammalian DNA transpososome as an obligate heterodimer

2026-07-16

Abstract excerpt

<h4>Summary</h4> Eukaryotic DNA transpososomes assemble as nucleoprotein complexes containing multiple identical transposase protomers. We determined the structure of the hyperactive Myotis lucifugus piggyBat transpososome and discovered that it uses an unusual crescent-shaped, asymmetric tetramer to synapse divergent inverted terminal repeats. We found that identical amino-acid sequence motifs adopt distinct ro...

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Identifiers and source

Literature Corpus work: 7987218d-ef69-5701-b772-c6a8887919db
DOI: 10.64898/2026.07.15.738711

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