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Article

Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems.

Molecular cell - 4 Mar 2021

Wang Beibei, Zhang Tianlong, Yin Jun, Yu You, Xu Wenhao, Ding Jianping, Patel Dinshaw J, Yang Hui

Abstract excerpt

Bacteria and archaea apply CRISPR-Cas surveillance complexes to defend against foreign invaders. These invading genetic elements are captured and integrated into the CRISPR array as spacer elements, guiding sequence-specific DNA/RNA targeting and cleavage. Recently, in vivo studies have shown that target RNAs with extended complementarity with repeat sequences flanking the target element (tag:anti-tag pairing)...

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Source

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Identifiers

PMID: 33472057
DOI: 10.1016/j.molcel.2020.12.033
PMCID: PMC8274241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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