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Article

Evolutionary and mechanistic diversity of Type I-F CRISPR-associated transposons.

Molecular cell - 3 Feb 2022

Klompe Sanne E, Jaber Nora, Beh Leslie Y, Mohabir Jason T, Bernheim Aude, Sternberg Samuel H

Abstract excerpt

Canonical CRISPR-Cas systems utilize RNA-guided nucleases for targeted cleavage of foreign nucleic acids, whereas some nuclease-deficient CRISPR-Cas complexes have been repurposed to direct the insertion of Tn7-like transposons. Here, we established a bioinformatic and experimental pipeline to comprehensively explore the diversity of Type I-F CRISPR-associated transposons. We report DNA integration for 20 systems...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35051352
DOI: 10.1016/j.molcel.2021.12.021
PMCID: PMC8849592

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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