Article

Somatic mutations in Alzheimer-associated tetraploid neurons

2024-01-15

Abstract excerpt

An early pathological process affecting the brain of Alzheimer’s disease (AD) is the reactivation of the cell cycle in neurons followed by somatic neuronal tetraploidization (NT). NT also increases with age, and ageing has been shown to correlate with the accumulation of DNA somatic mutations. In this study, we have evaluated the presence of somatic mutations including single nucleotide variants (SNVs) and indels...

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Literature Corpus work: 6de1e6df-6b16-5cf8-b397-6509d0f9ebe1
DOI: 10.1101/2024.01.13.24301214

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