Article

Aging and neurodegeneration are associated with increased mutations in single human neurons

2017-11-21

Abstract excerpt

<h4>Summary</h4> It has long been hypothesized that aging and neurodegeneration are associated with somatic mutation in neurons; however, methodological hurdles have prevented testing this hypothesis directly. We used single-cell whole-genome sequencing to perform genome-wide somatic single-nucleotide variant (sSNV) identification on DNA from 161 single neurons from the prefrontal cortex and hippocampus of fiftee...

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Literature Corpus work: b12f54c7-2869-5de2-b607-18df082b8e83
DOI: 10.1101/221960

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