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Single-neuron whole genome sequencing identifies increased somatic mutation burden in Alzheimer's disease related genes.

Neurobiology of aging - 1 Mar 2023

Li Zongchang, Min Shishi, Alliey-Rodriguez Ney, Giase Gina, Cheng Lijun, Craig David Wesley, Faulkner Geoffrey J, Asif Huma, Liu Chunyu, Gershon Elliot S

Abstract excerpt

Accumulation of somatic mutations in human neurons is associated with aging and neurodegeneration. To shed light on the somatic mutational burden in Alzheimer's disease (AD) neurons and get more insight into the role of somatic mutations in AD pathogenesis, we performed single-neuron whole genome sequencing to detect genome-wide somatic mutations (single nucleotide variants (SNVs) and Indels) in 96 single...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36599749
DOI: 10.1016/j.neurobiolaging.2022.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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