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The threat of programmed DNA damage to neuronal genome integrity and plasticity.

Nature genetics - 1 Feb 2022

Caldecott Keith W, Ward Michael E, Nussenzweig André

Abstract excerpt

The neuronal genome is particularly sensitive to loss or attenuation of DNA repair, and many neurological diseases ensue when DNA repair is impaired. It is well-established that the neuronal genome is subjected to stochastic DNA damage, most likely because of extensive oxidative stress in the brain. However, recent studies have identified unexpected high levels of 'programmed' DNA breakage in neurons, which we...

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PMID: 35145299
DOI: 10.1038/s41588-021-01001-y

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