Article

Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s disease

2025-05-30

Abstract excerpt

Tau deposition within neurons marks Alzheimer’s disease (AD) neuropathology, suggesting that tau may contribute to cellular dysfunction and death. In AD, somatic mutations accumulate in neurons, with features that suggest deleterious effects on cellular function. To examine the relationship between tau and somatic mutation, we isolated neurons according to tau pathology and performed single-cell whole-genome seque...

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Literature Corpus work: 89a05e53-3368-522b-8a0c-acd45a3a8499
DOI: 10.1101/2025.05.26.656152

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