Article

Identifying aging and Alzheimer’s disease associated somatic mutations in excitatory neurons from the human frontal cortex using whole genome sequencing and single cell RNA sequencing data

2022-05-26

Abstract excerpt

With age, somatic mutations accumulated in human brain cells can lead to various neurological disorders and brain tumors. Since the incidence rate of Alzheimer’s disease (AD) increases exponentially with age, investigating the association between AD and the accumulation of somatic mutation can help understand the etiology of AD. Here we built a somatic mutation detection pipeline by contrasting genotypes derived f...

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Literature Corpus work: 8e5e6252-813c-50d5-a79f-c7a1706334ac
DOI: 10.1101/2022.05.25.22275538

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