Article

Ultraspecific somatic SNV and indel detection in single neurons using primary template-directed amplification

2021-05-01

Abstract excerpt

Primary template-directed amplification (PTA) is an improved amplification technique for single-cell DNA sequencing. We generated whole-genome analysis of 76 single neurons and developed SCAN2, a computational method to accurately identify both clonal and non-clonal somatic (i.e., limited to a single neuron) single nucleotide variants (SNVs) and small insertions and deletions (indels) using PTA data. Our analysis...

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Literature Corpus work: 6c812289-79a6-5d59-b4f7-75a4c0c9af33
DOI: 10.1101/2021.04.30.442032

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