Article

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders

2025-03-05

Abstract excerpt

<h4>SUMMARY</h4> Amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Alzheimer’s disease (AD) represent two major categories of neurodegenerative disorders—TDP-43 and tau proteinopathies—for which the mechanisms driving neuronal death remain unclear. Single-cell whole-genome sequencing of 469 neurons from C9ORF72 ALS, C9ORF72 FTD, AD, and control brains revealed increased somatic single nucl...

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Literature Corpus work: 00bbcc9a-7ad0-5797-ad17-8281404d7728
DOI: 10.1101/2025.03.03.641186

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