Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration.

Molecular neurodegeneration - 9 Oct 2025

Li Zuguang, Zhang Juan, Liu Zhiqiang, Yu Lu, Yang Chunqing, Zhang Luoman, Xiang Zhigao, Hu Feng, Brazh Nadezda, Shu Kai, Zhu Ling-Qiang, Liu Dan

Abstract excerpt

Somatic mutations are DNA sequence changes that occur in non-reproductive cells during an organism's life and are not inherited by offspring. Growing evidence implicates somatic mutations in Alzheimer's disease (AD), linking them to both disease onset and progression. Recent advancements in single-cell sequencing and genome-wide analyses have revealed higher mutation burdens in neurons, particularly in AD-related...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to PSEN1 gene

Share to PSEN2 gene

Share to Mosaicism

Share to Mutation

Share to Presenilin-1

Share to Presenilin-2

Source

Open in PubMed Open full text

Identifiers

PMID: 41068782
DOI: 10.1186/s13024-025-00895-0
PMCID: PMC12512383

Genes

APP
PSEN1
PSEN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain somatic mutations in Alzheimer's disease: linking genetic mosaicism to neurodegeneration.PMID 41068782Read ↗

Somatic mutations in neurodegeneration: An update.Semantic proximity Read ↗

Brain Somatic Mutation in Aging and Alzheimer's Disease.Semantic proximity Read ↗

Single-neuron whole genome sequencing identifies increased somatic mutation burden in Alzheimer's disease related genes.Semantic proximity Read ↗

Review: Somatic mutations in neurodegeneration.Semantic proximity Read ↗

Somatic Mutations and Alzheimer's Disease.Semantic proximity Read ↗

Neurons accumulate disease-specific somatic genomic changes across tau pathologic states in Alzheimer’s diseaseSemantic proximity Read ↗

Somatic mosaicism in amyotrophic lateral sclerosis and frontotemporal dementia identifies focal mutations associated with widespread degenerationSemantic proximity Read ↗

On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients.Semantic proximity Read ↗

Somatic mosaicism in ALS and FTD identifies focal mutations associated with widespread degeneration.Semantic proximity Read ↗

Single-cell mosaicism analysis reveals cell-type-specific somatic mutational burden in Alzheimer’s DementiaSemantic proximity Read ↗

Identifying aging and Alzheimer’s disease associated somatic mutations in excitatory neurons from the human frontal cortex using whole genome sequencing and single cell RNA sequencing dataSemantic proximity Read ↗

Disease insights from brain somatic mosaicism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.