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Article

Genomic Mosaicism Formed by Somatic Variation in the Aging and Diseased Brain.

Genes - 14 Jul 2021

Costantino Isabel, Nicodemus Juliet, Chun Jerold

Abstract excerpt

Over the past 20 years, analyses of single brain cell genomes have revealed that the brain is composed of cells with myriad distinct genomes: the brain is a genomic mosaic, generated by a host of DNA sequence-altering processes that occur somatically and do not affect the germline. As such, these sequence changes are not heritable. Some processes appear to occur during neurogenesis, when cells are mitotic,...

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Identifiers

PMID: 34356087
DOI: 10.3390/genes12071071
PMCID: PMC8305509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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