Article

Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress

2017-01-12

Abstract excerpt

Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base variations measuring up to 0.48% of the total variations. Interestingly, about 64% of these somatic variations in the brain are expected to lead to non-synonymous changes,...

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Literature Corpus work: a1ea371a-d35d-52f2-b2fb-9277b852728a
DOI: 10.12688/f1000research.9495.3

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