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Article

Brain Somatic Mutation in Aging and Alzheimer's Disease.

Annual review of genomics and human genetics - 31 Aug 2021

Miller Michael B, Reed Hannah C, Walsh Christopher A

Abstract excerpt

Somatic mutations arise postzygotically, producing genetic differences between cells in an organism. Well established as a driver of cancer, somatic mutations also exist in nonneoplastic cells, including in the brain. Technological advances in nucleic acid sequencing have enabled recent breakthroughs that illuminate the roles of somatic mutations in aging and degenerative diseases of the brain. Somatic mutations...

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PMID: 33979534
DOI: 10.1146/annurev-genom-121520-081242
PMCID: PMC8612367

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