Back to search

Article

Engineered Reproductively Isolated Species Drive Reversible Population Replacement

2020-08-10

Abstract excerpt

Engineered reproductive species barriers are useful for impeding gene flow and driving desirable genes into wild populations in a reversible threshold-dependent manner. However, methods to generate synthetic barriers are lacking in advanced eukaryotes. To overcome this challenge, we engineered SPECIES ( S ynthetic P ostzygotic barriers E xploiting C RISPR-based I ncompatibilities for E ngineering S pecies)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6b25dc8e-e2ce-5dfe-844d-911c6a8a1a19
DOI
10.1101/2020.08.09.242982
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Engineered Reproductively Isolated Species Drive Reversible Population ReplacementDOI 10.1101/2020.08.09.242982
Rationally-engineered reproductive barriers using CRISPR & CRISPRa: an evaluation of the synthetic species concept in <i>Drosophila melanogaster</i>Semantic proximity
Concerning RNA-guided gene drives for the alteration of wild populations.Semantic proximity
Novel CRISPR/Cas9 gene drive constructs in <i>Drosophila</i> reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populationsSemantic proximity
Concerning RNA-Guided Gene Drives for the Alteration of Wild PopulationsSemantic proximity
Population suppression by release of insects carrying a dominant sterile homing gene drive targeting <i>doublesex</i> in <i>Drosophila</i>Semantic proximity
Resistance is futile: A CRISPR homing gene drive targeting a haplolethal geneSemantic proximity
A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance allelesSemantic proximity
Split-gene drive system provides flexible application for safe laboratory investigation and potential field deploymentSemantic proximity
Self-limiting population suppression gene drive design in the West Nile vector mosquito, Culex quinquefasciatus.Semantic proximity
A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment.Semantic proximity
Current CRISPR gene drive systems are likely to be highly invasive in wild populations.Semantic proximity
A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in <i>Drosophila</i>Semantic proximity
Select a neighboring publication to make it the new centre.