Split-gene drive system provides flexible application for safe laboratory investigation and potential field deployment

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR-based gene drives spread through populations bypassing the dictates of Mendelian genetics, offering a population-engineering tool for tackling vector-borne diseases, managing crop pests, and helping island conservation efforts; unfortunately, current technologies raise safety concerns for unintended gene propagation. Herein, we address this by splitting the two drive components, Cas9 and...

Topics

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• Animals, Genetically Modified
• CRISPR-Cas Systems
• Diptera
• Gene Editing
• Genes, X-Linked
• Models, Theoretical
• RNA, Guide, CRISPR-Cas Systems
• Transgenes

Identifiers and source

Literature Corpus work

ba64a21f-72a3-5078-a7bb-2ef294960fe2

DOI

10.1101/684597