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Article

Concerning RNA-guided gene drives for the alteration of wild populations.

eLife - 17 Jul 2014

Esvelt Kevin M, Smidler Andrea L, Catteruccia Flaminia, Church George M

Abstract excerpt

Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR nuclease Cas9 to serve as a general method for spreading altered traits through wild populations over many generations. We detail likely capabilities,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25035423
DOI: 10.7554/eLife.03401
PMCID: PMC4117217

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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