A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in <i>Drosophila</i>

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR-based gene-drive systems have been proposed for managing insect populations, including disease-transmitting mosquitoes, due to their ability to bias their inheritance towards super-Mendelian rates (>50%). Current technologies employ a Cas9 that introduces DNA double-strand breaks into the opposing wildtype allele to replace it with a copy of the gene drive allele via DNA homology-directed...

Topics

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• Alleles
• CRISPR-Cas Systems
• Gene Editing
• Genetics, Population
• Models, Genetic
• Mutation
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

1dbbe85e-4101-5bf3-ac66-6f7d0c9e04c8

DOI

10.1101/2021.12.01.470847