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Article

A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment.

Nature communications - 17 Jan 2020

López Del Amo Víctor, Bishop Alena L, Sánchez C Héctor M, Bennett Jared B, Feng Xuechun, Marshall John M, Bier Ethan, Gantz Valentino M

Abstract excerpt

CRISPR-based gene drives can spread through wild populations by biasing their own transmission above the 50% value predicted by Mendelian inheritance. These technologies offer population-engineering solutions for combating vector-borne diseases, managing crop pests, and supporting ecosystem conservation efforts. Current technologies raise safety concerns for unintended gene propagation. Herein, we address such...

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Identifiers

PMID: 31953404
DOI: 10.1038/s41467-019-13977-7
PMCID: PMC6969112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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