Article
A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment.
Nature communications - 17 Jan 2020
López Del Amo Víctor, Bishop Alena L, Sánchez C Héctor M, Bennett Jared B, Feng Xuechun, Marshall John M, Bier Ethan, Gantz Valentino M
Abstract excerpt
CRISPR-based gene drives can spread through wild populations by biasing their own transmission above the 50% value predicted by Mendelian inheritance. These technologies offer population-engineering solutions for combating vector-borne diseases, managing crop pests, and supporting ecosystem conservation efforts. Current technologies raise safety concerns for unintended gene propagation. Herein, we address such...
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