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Novel CRISPR/Cas9 gene drive constructs in <i>Drosophila</i> reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

2017-02-27

Abstract excerpt

<h4>ABSTRACT</h4> A functioning gene drive system could fundamentally change our strategies for the control of vector-borne diseases by facilitating rapid dissemination of transgenes that prevent pathogen transmission or reduce vector capacity. CRISPR/Cas9 gene drive promises such a mechanism, which works by converting cells that are heterozygous for the drive construct into homozygotes, thereby enabling super-Me...

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Literature Corpus work
b0608b95-8040-5c3d-a64d-40d91092b476
DOI
10.1101/112011
Open publication

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Novel CRISPR/Cas9 gene drive constructs in <i>Drosophila</i> reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populationsDOI 10.1101/112011
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