Concerning RNA-Guided Gene Drives for the Alteration of Wild Populations

Abstract excerpt

Gene drives may be capable of addressing ecological problems by altering entire populations of wild organisms, but their use has remained largely theoretical due to technical constraints. Here we consider the potential for RNA-guided gene drives based on the CRISPR nuclease Cas9 to serve as a general method for spreading altered traits through wild populations over many generations. We detail likely capabilities,...

Topics

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• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR-Associated Proteins
• CRISPR-Cas Systems
• Gene Editing
• Gene Expression Regulation, Plant
• Plants, Genetically Modified
• Risk Assessment
• RNA, Guide, CRISPR-Cas Systems

Identifiers and source

Literature Corpus work

2adea54f-d856-5b54-8907-eafad2fac4f1

DOI

10.1101/007203