Article
Current CRISPR gene drive systems are likely to be highly invasive in wild populations.
eLife - 19 Jun 2018
Noble Charleston, Adlam Ben, Church George M, Esvelt Kevin M, Nowak Martin A
Abstract excerpt
Recent reports have suggested that self-propagating CRISPR-based gene drive systems are unlikely to efficiently invade wild populations due to drive-resistant alleles that prevent cutting. Here we develop mathematical models based on existing empirical data to explicitly test this assumption for population alteration drives. Our models show that although resistance prevents spread to fixation in large...
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