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Article

Self-limiting population suppression gene drive design in the West Nile vector mosquito, Culex quinquefasciatus.

Nature communications - 26 May 2026

Feng Xuechun, Ding Jinying, Liu Yiran, Lopez Del Amo Victor, Gantz Valentino M, Chen Xue-Xin, Champer Jackson, Liu Feng

Abstract excerpt

Culex quinquefasciatus is a major vector of West Nile virus and other pathogens, yet genetic population suppression tools for this species remain limited. Here, we develop a self-limiting, CRISPR-based suppression gene drive system targeting doublesex, close to the male-determining locus, promoting male transmission. A recoded dsxM sequence converts females into sterile intersexes, preventing population-level...

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Identifiers

PMID: 42191711
DOI: 10.1038/s41467-026-73641-9
PMCID: PMC13389367

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