Article

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombination

2026-04-29

Abstract excerpt

Telomerase maintains chromosome ends by extending telomeric DNA, yet how recruited telomerase becomes productively engaged remains poorly understood. Recent studies found that Replication Protein A (RPA) contributes to telomerase stimulation through interaction with TERT in humans and with the TPP1 ortholog Est3 in budding yeast, suggesting a direct role in telomerase activation. Here, we provide genetic and struc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69442ede-db21-5706-bbe0-aebd728a8d34
DOI: 10.64898/2026.04.26.720725

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombinationDOI 10.64898/2026.04.26.720725Read

Human Replication Protein A complex is a Telomerase Processivity Factor Essential for Telomere MaintenanceSemantic proximity Read

Fission yeast Taz1 and RPA are synergistically required to prevent rapid telomere loss.Semantic proximity Read

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read

Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsSemantic proximity Read

Interaction hub critical for telomerase recruitment and primer-template handling for catalysis.Semantic proximity Read

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.Semantic proximity Read

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Semantic proximity Read

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.Semantic proximity Read

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read