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Structural basis of human telomerase recruitment by TPP1-POT1

10 Mar 2022

Abstract excerpt

Telomerase maintains genome stability by extending the 3' telomeric repeats at eukaryotic chromosome ends, thereby counterbalancing progressive loss caused by incomplete genome replication. In mammals, telomerase recruitment to telomeres is mediated by TPP1, which assembles as a heterodimer with POT1. We report structures of DNA-bound telomerase in complex with TPP1 and with TPP1-POT1 at 3.2- and 3.9-angstrom...

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PMID: 35201900
DOI: 10.1126/science.abn6840

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