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Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in Yeasts

29 Mar 2016

Abstract excerpt

Rap1-interacting factor 1 (Rif1) was originally identified in the budding yeast Saccharomyces cerevisiae as a telomere-binding protein that negatively regulates telomerase-mediated telomere elongation. Although this function is conserved in the distantly related fission yeast Schizosaccharomyces pombe, recent studies, both in yeasts and in metazoans, reveal that Rif1 also functions more globally, both in the...

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PMID: 27066066
DOI: 10.3389/fgene.2016.00045

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Related research

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Rif1: A Conserved Regulator of DNA Replication and Repair Hijacked by Telomeres in YeastsPMID 27066066Read ↗

RIF1: A novel regulatory factor for DNA replication and DNA damage response signalingSemantic proximity Read ↗

Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks.Semantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

Functional diversification of yeast telomere associated protein, Rif1, in higher eukaryotesSemantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.Semantic proximity Read ↗

Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

Rif1 acts through Protein Phosphatase 1 but independent of replication timing to suppress telomere extension in budding yeast.Semantic proximity Read ↗

Telomere shortening triggers a feedback loop to enhance end protection.Semantic proximity Read ↗

Human RAP1 specifically protects telomeres of senescent cells from DNA damageSemantic proximity Read ↗

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombinationSemantic proximity Read ↗

Rif1 Regulates the Fate of DNA Entanglements during MitosisSemantic proximity Read ↗

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