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Article

Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.

Science (New York, N.Y.) - 6 Jun 2008

Miyoshi Tomoichiro, Kanoh Junko, Saito Motoki, Ishikawa Fuyuki

Abstract excerpt

Telomeres are specialized chromatin structures that protect chromosomal ends. Protection of telomeres 1 (Pot1) binds to the telomeric G-rich overhang, thereby protecting telomeres and regulating telomerase. Mammalian POT1 and TPP1 interact and constitute part of the six-protein shelterin complex. Here we report that Tpz1, the TPP1 homolog in fission yeast, forms a complex with Pot1. Tpz1 binds to Ccq1 and the...

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Source

Identifiers

PMID: 18535244
DOI: 10.1126/science.1154819

Genes

TPP1
POT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.PMID 18535244Read ↗

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Protection of telomeres by a conserved Stn1–Ten1 complexSemantic proximity Read ↗

Structural and functional analysis of the human POT1-TPP1 telomeric complex.Semantic proximity Read ↗

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.Semantic proximity Read ↗

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Human Pot1 (Protection of Telomeres) Protein: Cytolocalization, Gene Structure, and Alternative SplicingSemantic proximity Read ↗

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