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Article

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.

eLife - 2 Jun 2016

Hu Xichan, Liu Jinqiang, Jun Hyun-Ik, Kim Jin-Kwang, Qiao Feng

Abstract excerpt

Tightly controlled recruitment of telomerase, a low-abundance enzyme, to telomeres is essential for regulated telomere synthesis. Recent studies in human cells revealed that a patch of amino acids in the shelterin component TPP1, called the TEL-patch, is essential for recruiting telomerase to telomeres. However, how TEL-patch-telomerase interaction integrates into the overall orchestration of telomerase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27253066
DOI: 10.7554/eLife.15470
PMCID: PMC4936895

Genes

TPP1
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.PMID 27253066Read ↗

The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.Semantic proximity Read ↗

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.Semantic proximity Read ↗

Fission Yeast Tel1ATM and Rad3ATR Promote Telomere Protection and Telomerase RecruitmentSemantic proximity Read ↗

Identification of human TERT elements necessary for telomerase recruitment to telomeres.Semantic proximity Read ↗

Tel1ATM and Rad3ATR kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast.Semantic proximity Read ↗

Interaction hub critical for telomerase recruitment and primer-template handling for catalysis.Semantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitmentSemantic proximity Read ↗

The structurally conserved TELR region on shelterin protein TPP1 is essential for telomerase processivity but not recruitment.Semantic proximity Read ↗

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.Semantic proximity Read ↗

Structural basis of human telomerase recruitment by TPP1-POT1Semantic proximity Read ↗

Characterization of novel mutations in the TEL-patch domain of the telomeric factor TPP1 associated with telomere biology disorders.Semantic proximity Read ↗

Structural and functional consequences of a disease mutation in the telomere protein TPP1.Semantic proximity Read ↗

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