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Article

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.

Nature structural & molecular biology - 1 Feb 2011

Chen Yong, Rai Rekha, Zhou Zi-Ren, Kanoh Junko, Ribeyre Cyril, Yang Yuting, Zheng Hong, Damay Pascal, Wang Feng, Tsujii Hisayo, Hiraoka Yasushi, Shore David, Hu Hong-Yu, Chang Sandy, Lei Ming

Abstract excerpt

Repressor activator protein 1 (RAP1) is the most highly conserved telomere protein. It is involved in protecting chromosome ends in fission yeast and promoting gene silencing in Saccharomyces cerevisiae, whereas it represses homology-directed recombination at telomeres in mammals. To understand how RAP1 has such diverse functions at telomeres, we solved the crystal or solution structures of the RAP1 C-terminal...

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Identifiers

PMID: 21217703
DOI: 10.1038/nsmb.1974
PMCID: PMC3688267

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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