Article
Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.
The EMBO journal - 7 Sept 2005
Miller Kyle M, Ferreira Miguel Godinho, Cooper Julia Promisel
Abstract excerpt
Telomere protection and maintenance are accomplished through the coordinated actions of telomere-specific DNA binding proteins and their interacting partners. The fission yeast ortholog of human TRF1/2, Taz1, binds telomeric DNA and regulates numerous aspects of telomere function. Here, we ask which aspects of Taz1 function are mediated through its interacting proteins, Rap1 and Rif1. We demonstrate that rap1+...
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