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Article

Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.

Genes & development - 1 Sept 2013

Jun Hyun-Ik, Liu Jinqiang, Jeong Heetae, Kim Jin-Kwang, Qiao Feng

Abstract excerpt

Telomeres are nucleoprotein complexes comprising telomeric DNA repeats bound by the multiprotein shelterin complex. A dynamic binary switch between telomerase-extendible and telomerase-nonextendible telomeric states determines telomere length homeostasis. However, the molecular nature of the nonextendible state is largely unknown. Here, we show that, in fission yeast, Tpz1 (the ortholog of human TPP1)-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24013504
DOI: 10.1101/gad.219485.113
PMCID: PMC3778244

Genes

TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.PMID 24013504Read ↗

Fission yeast Ccq1 is a modulator of telomerase activity.Semantic proximity Read ↗

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Taz1, Rap1 and Rif1 act both interdependently and independently to maintain telomeres.Semantic proximity Read ↗

Unravelling the Intricacies of Telomere Replication: A Molecular ConundrumSemantic proximity Read ↗

Evolution of CST function in telomere maintenanceSemantic proximity Read ↗

Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.Semantic proximity Read ↗

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces.Semantic proximity Read ↗

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhangSemantic proximity Read ↗

Fission yeast RPA–TERT–Tpz1 <sup>TPP1</sup> complex promotes telomere extension and suppresses telomere recombinationSemantic proximity Read ↗

Telomere‐associated proteins: cross‐talk between telomere maintenance and telomere‐lengthening mechanismsSemantic proximity Read ↗

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