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Article

Interaction hub critical for telomerase recruitment and primer-template handling for catalysis.

Life science alliance - 1 Jun 2023

Padmanaban Shilpa, Tesmer Valerie M, Nandakumar Jayakrishnan

Abstract excerpt

Telomerase processively adds telomeric DNA repeats to chromosome ends using catalytic protein subunit TERT and a template on its RNA subunit TR. Mammalian telomerase is recruited to telomeres by the TEL patch and NOB regions of shelterin component TPP1. Recent cryo-EM structures of human telomerase reveal that a composite TERT TEN-(IFD-TRAP) domain interacts with TPP1. Here, we generate TERT mutants to...

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Identifiers

PMID: 36963832
DOI: 10.26508/lsa.202201727
PMCID: PMC10055720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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