Article
RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends.
The EMBO journal - 14 Jul 2015
Audry Julien, Maestroni Laetitia, Delagoutte Emmanuelle, Gauthier Tiphaine, Nakamura Toru M, Gachet Yannick, Saintomé Carole, Géli Vincent, Coulon Stéphane
Abstract excerpt
Replication protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-binding protein involved in DNA replication, recombination, and repair. In fission yeast, the Rpa1-D223Y mutation provokes telomere shortening. Here, we show that this mutation impairs lagging-strand telomere replication and leads to the accumulation of secondary structures and recruitment of the homologous recombination factor...
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